Breast cancer research and treatment 145 (1), 61-71, 2014. 56, 2014 receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral …

Diagnostic work-up of contralateral breast cancers has not improved over calendar period. Breast. Cancer Res 2010;122:889-895. 19. Edgren G, Hjalgrim H.

Metachronous Contralateral Breast Cancer Synchronous Bilateral Breast Cancer Unilateral Cancer Growing Life Expectancy Second Cancer These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. 1999-10-01 Increasing breast density had a dose-dependent effect on the risk of contralateral breast cancer. Relative to 'almost entirely fat' category of breast density, the adjusted odds ratios (and p values) in the multivariate analysis for 'scattered density,' 'heterogeneously dense,' and 'extremely dense' categories were 1.65 (0.036), 2.10 (0.002), and 2.32 (0.001), respectively. 2020-04-17 We undertook a double-blind, randomised, placebo-controlled trial to compare anastrozole with tamoxifen for the prevention of locoregional and contralateral breast cancer.

2021-04-10 · A few cases of NF1 patients with contralateral breast cancer have been identified in the literature, and our case highlights an NF1 patient who developed contralateral breast cancer nearly four decades after her initial breast cancer diagnosis. It has been suggested that NF1 patients may be at higher risk of developing contralateral breast cancer. 2020-11-05 · In the case-case series, a CBC was defined as a breast cancer (in situ or invasive) in the contralateral breast irrespective of the time since the first breast cancer. The case-case series comprised 81,000 women with unilateral breast cancer, 3,607 women with CBC, and 62,830 women without any diagnosis of breast cancer ( Figure S1 A). With MRI screening, there may be a 4-10% rate of contralateral breast cancers when a unilateral breast cancer is found 1. Treatment and prognosis The survival of women with synchronous breast cancers is worse than those with unilateral disease 3 . The risk of a contralateral breast cancer, the decision-making process to undergo a CPM, and outcomes will be reviewed in this topic.

We undertook a double-blind, randomised, placebo-controlled trial to compare anastrozole with tamoxifen for the prevention of locoregional and contralateral breast cancer. Participants were women aged 40–70 years, postmenopausal, and had DCIS diagnosed within 6 months before randomisation. Microinvasion of less than 1 mm was permitted.

2 Because breast cancer is the most Contralateral breast cancer: incidence according to ductal or lobular phenotype of the primary There is no apparent increase in risk of developing a contralateral breast cancer according to the primary cancer histology either IDC or ILC. Standard mammographic follow-up does not need to take account of original tumour pathology. Background: Women with ductal carcinoma in situ (DCIS) are increasingly choosing bilateral mastectomy. We sought to quantify rates of contralateral breast cancer (CBC) and ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) for DCIS, and to compare risk factors for CBC and IBTR.

May 13, 2020 While most women never will develop a contralateral second primary breast cancer, risk-reducing strategies may be appropriate for some. A

2000; 36:2288)”. (M1), including cervical or contralateral internal mammary lymph nodes.

Author information: (1)Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Contralateral breast cancers are divided in those that are synchronous, that is, when breast cancers are diagnosed in both breasts simultaneously, and metachronous, normally defined as diagnosed more than 6 months from the first cancer. The age-specific incidence of synchronous breast cancer mimics that of unilateral breast cancer.
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Edgren G, Hjalgrim H. Abstract P6-08-11: Association between genetic testing for hereditary breast cancer and contralateral prophylactic mastectomy among young women diagnosed sen för primär bröstcancer väsentligen förbättrats och breast cancer 1), och funnit att tumörut- tryck av nosis of metachronous contralateral breast cancer.

Microinvasion of less than 1 mm was permitted. An increasing number of breast cancer patients are undergoing expanded genetic testing and are being identified as germline mutation carriers. We sought to determine rates of contralateral risk-reducing mastectomy (CRRM) in patients with various germline mutations. All women ≥ 18 years of age with unilateral breast cancer who underwent multigene panel testing between January 1, 2014 and Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers in a large cohort of unselected Chinese breast cancer patients Liming Su Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital & Institute, Peking University Cancer Hospital, Beijing, People's Republic of China 2019-09-09 · Breast cancer survival and risk of contralateral breast cancer.a Contralateral breast cancer incidence after the first breast cancer in female patients with neurofibromatosis 1 (NF1) compared with In a multicentre, population-based, case-control study of 1521 contralateral breast cancer cases against 2212 matched controls of unilateral breast cancer, Reiner demonstrated that non-mutation carriers with any 1st or 2nd degree relative of breast cancer had a nearly two-fold increased contralateral breast cancer risk (RR 1.8, 95% CI 1.3–2.4), compared to individuals without a family history.
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2015-02-04

Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing.